Assessment of hematologic progenitor engraftment by complete reticulocyte maturation parameters after autologous and allogeneic hematopoietic stem cell transplantation

By ANTONIO TORRES, JOAQUIN SÁNCHEZ, DIDIER LAKOMSKY,* JOSEFINA SERRANO, MIGUEL A. ALVAREZ, CARMEN MARTÍN, CARMEN VALLS, LOURDES NEVADO, ANTONIA RODRIGUEZ, JAVIER CASAÑO, FRANCISCO MARTÍNEZ, PEDRO GÓMEZ-
07/07/2020

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Hematopoietic restoration after marrow ablation is initiated by the erythroid compartment. However, the absolute microscope counts or
corrected percentage of reticulocytes have proven to be poor markers of hematopoietic engraftment. Some reports have highlighted the usefulness of automatic flow cytometry methods to determine highly fluorescent reticulocytes, or mean fluorescence index. In this series of 60 hematopoietic stem cell transplants, we sought the normal kinetics throughout the post-transplant period of the following
reticulocyte maturing parameters: highly fluorescent reticulocytes (RETH), immature reticulocyte fraction (IRF), mean fluorescence index (MFI) and also mean reticulocyte volume (MRV).

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