Howell-Jolly body-like inclusions (HJBLIs) have been classically associated with human immunodeficiency virus (HIV)-infected patients, patients on antiviral medications, and immunosuppressed individuals. These inclusions appear in neutrophils, and unlike Barr bodies, are completely detached inclusions in the cytoplasm. They are also seen in Covid 19 infected patients. Differential diagnosis: The presence of these spherical, basophilic inclusions within the cytoplasm of neutrophils raises immediate concern for an infectious etiology, the main differential of which is typically either Anaplasmosis or Ehrlichiosis, which presents with similar appearing cytoplasmic inclusions. We express our sincere gratitude to Dr. CN Srinivas for his contribution in this.