Promonocytes

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Promonocytes are considered as monoblastic equivalents when the requisite percentage of blasts is tallied for the diagnosis of acute monoblastic, acute monocytic, or acute myelomonocytic leukaemia and in subclassifying chronic myelomonocytic leukaemia. Diagnosis: 1.Peripheral smear and bone marrow morphology - Promonocytes large cells with irregular and delicately folded nuclei and nuclear indentation with fine chromatin, small indistinct nucleoli, and finely granulated cytoplasm. 2.Special cytochemistry: Positive for Nonspecific esterase & Myeloperoxidase 3.On Flow cytometry: These cells fall in the monocytic region and shows that these variably express the myeloid antigens CD13, CD33 (often very bright), CD15, and CD65. •There is generally expression of at least two markers characteristic of monocytic differentiation, such as CD14, CD4, CDI1b, CD11c, CD64 (bright), CD68, CD36 (bright), and lysozyme. •CD34 is positive in only 30% of cases, whereas KIT (CD117) is more often expressed. Most cases are positive for HLA-DR. We express our sincere gratitude to Dr.Pradeep Arumugam for his contribution and support in this.

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