Sickle cells are thin, elongated crescent shape red cells with pointed ends. Sickle shape of RBC is due to presence of HbS that is result of mutation in 6th position of globin chain. Clinical significance: Sickle cells are seen in sickle cell disorders. In state of low oxygen tension, polymerization of HbS occurs leading to sickle shape of red blood cell. Most of the clinical signs and symptoms are because of chronic hemolytic anemia and episodic vaso occlusive events leading to periodic episode of acute pain. We express our sincere gratitude to Dr. Saloni Dwivedi for her valuable contribution in this.