Signet ring cell

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Signet ring cells are defined as tumor cells with prominent cytoplasmic mucin and a crescent shaped nucleus eccentrically placed. They can be seen by examining the cytology samples or histopathological examination of organs involved or fluid cytology in case of carcinomatosis. Clinical significance: These cells are most frequently associated with gastric adenocarcinomas but can less frequently arise from other tissues like prostate, bladder, gallbladder, breast, colon, ovarian stroma and testis Signet-ring cell adenocarcinoma is associated with more advanced cancer, associated with worse prognosis and is more frequent in Stage 4, T3/T4 and N2 cancers. We express our sincere gratitude to Dr Kanika Gupta for her valuable contribution in this.

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